Oh, I've got a couple of these.

Now, my hometown is now and has for more than a century been known as Elkins, which is easy and straightforward to pronouns. (You've got elk, ins, y'see.) This town was built, however, when a couple of railroad robber barons (Senators Stephen Benton Elkins and Henry Gassaway Davis, son and father in law respectively) needed a junction and depot and decided to build a company town around it...

The village that was in more or less the same place before they moved into the area, however, was named Leadsville. (lead a horse to water...)

My current place of employment, meanwhile, is Canaan Valley Resort and Conference Center, which anybody who's even remotely up on his bible study can pronounce...

...wrong. CANE-an is in the Holy Land. The high valley in West Virginia is Kuh-NANE.

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"V, did you do something foolish?"

"Yes, and it was glorious."