Speaking of anthropomorphized weapons being given anime, there's the Farmville-Clone-From-Hell Kantai Collection, which features cute humanoid versions of WWII-era warships. While it's somewhat creepy (this being Japan, all the ships are IJN vessels, so none of them have real happy backgrounds), there's a certain je ne sais quoi about the way they handle the "living weapons" concept that could be put to good use somewhere, I think.

"This is probably a stupid question, but . . ."